化工社化工社 化学情報印刷レポート · 研究参考用
HRID 629599作成日：2026年10月26日
4-Chloro-3-nitrobenzenesulfonamide → 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide
https://huagongshe.com/reaction/629599
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(2-Methoxyethyl)piperidin-4-amine | HCID 20119121 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide | HCID 68406613 | — |
反応手順
1-(2-Methoxy-ethyl)-piperidin-4-ylamine (2.01 g) and triethylamine (3.24 mL, 2.35 g) were added to 1,4-dioxane (60 mL). 4-Chloro-3-nitrobenzenesulfonamide (2.50 g) was added, and the mixture was heated to 90° C. for 16 hours. The mixture was cooled and the material purified by flash column chromatography on silica gel using 10% methanol in dichloromethane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09315488B2 |
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| 出典データセット | uspto-grants-2016_04 |
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| ORD ID | ord-1158022bd4ec41c8aca24c74d2ca769e |
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| 出典メモ | uspto-grants-2016_04 |
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