Dimethyl L-glutamate hydrochloride → HCID 21951876、化合物

HRID 629673

反応式

HRID 629673 の反応式
Cl.C[O:3]C(=O)[C@H](CCC(OC)=O)N.COC(=O)[C@H](CCC(OC)=O)NN[C:20](=[O:38])[C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])=[CH:23][C:22]=1[N+:35]([O-:37])=[O:36]>>[C:31]([O:30][C:28]([NH:27][C:24]1[CH:25]=[CH:26][C:21]([C:20]([OH:38])=[O:3])=[C:22]([N+:35]([O-:37])=[O:36])[CH:23]=1)=[O:29])([CH3:32])([CH3:33])[CH3:34]

参加物

3

反応物 2

HCID 12917568Dimethyl L-glutamate hydrochlorideHCID 68698082HCID 68698082、化合物

生成物 1

HCID 21951876HCID 21951876、化合物

実験手順

The synthesis was achieved in analogy to example 2 by using L-glutamic acid-dimethylester-hydrochloride instead of the L-glutamic acid-di-tert.-butylester-hydrochloride. From 14.8 g of 4-(tert-butoxycarbonylamino)-2-nitrobenzoic acid 27.4 g of crude dimethyl-N-(4-(tert.-butoxycarbonylamino)-2-nitrobenzamido)-L-glutamate were obtained which were purified twice by flash chromatography using silicagel 60 and ethylacetate/n-heptane/65:35 as eluent. After purification 17.38 g of dimethyl-N-(4-(tert.-butoxycarbonylamino)-2-nitrobenzamido)-L-glutamate were obtained.

出典と根拠

ORDレコード
ord-544de6a785b647f7bf958392ab384f19
出典データセット
uspto-grants-2016_04
特許番号
US09315506B2

関連ノート

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