n-(6-Nitro-2,3-dihydrobenzofuran-5-yl)acetamide → 6-Nitro-2,3-dihydrobenzofuran-5-amine

HRID 629680ノート

反応式

HRID 629680 の反応式
C([NH:4][C:5]1[C:6]([N+:14]([O-:16])=[O:15])=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)(=O)C>OS(O)(=O)=O>[NH2:4][C:5]1[C:6]([N+:14]([O-:16])=[O:15])=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1

参加物

3

反応物 1

HCID 13069186n-(6-Nitro-2,3-dihydrobenzofuran-5-yl)acetamide

生成物 1

HCID 130691876-Nitro-2,3-dihydrobenzofuran-5-amine収率 70.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
0 °C

実験手順

The product obtained in Step 4 (7.0 g, 31.5 mmol) and 2 mol/L H2SO4 solution (200 mL) were heated to reflux for 6 h. Then the reaction mixture was cooled to 0° C., filtered, washed with water, concentrated under vacuum and dried to obtain a product (4.0 g, 70%).

後処理

  1. temperatureto reflux for 6 h
  2. filtrationfiltered
  3. washwashed with water
  4. concentrationconcentrated under vacuum
  5. customdried

出典と根拠

ORDレコード
ord-71212763c13743369d9447afc60f9f06
出典データセット
uspto-grants-2016_04
特許番号
US09315513B2

反応ノート

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