2-Chloromethyl-6-cyclobutylsulfanyl-pyridine → 2-[3-Chloro-4-(6-cyclobutylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

HRID 62978ノート

反応式

HRID 62978 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]2[CH2:13][CH2:12][CH2:11]2)[N:4]=1.C([O:16][C:17]([CH:19]1[CH2:21][CH:20]1[C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([Cl:29])[CH:23]=1)=[O:18])C>>[Cl:29][C:24]1[CH:23]=[C:22]([CH:20]2[CH2:21][CH:19]2[C:17]([OH:18])=[O:16])[CH:27]=[CH:26][C:25]=1[O:28][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]2[CH2:13][CH2:12][CH2:11]2)[N:4]=1

参加物

3

反応物 2

HCID 901181462-Chloromethyl-6-cyclobutylsulfanyl-pyridineHCID 901181992-(3-Chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

生成物 1

HCID 742229752-[3-Chloro-4-(6-cyclobutylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid収率 84%

実験手順

2-Chloromethyl-6-cyclobutylsulfanyl-pyridine (52 mg, 0.26 mmol) obtained in Step C of Preparation Example 37 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (70 mg, 0.29 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (77 mg, 84%).

後処理

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

出典と根拠

ORDレコード
ord-27a41ffd5687455e99c16a507501f280
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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