Phosphorus tribromide → 3-(Bromomethyl)quinoline

HRID 629999

反応式

HRID 629999 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH2:11]O)[CH:2]=1.[Br:13]P(Br)Br>ClCCl>[Br:13][CH2:11][C:3]1[CH:2]=[N:1][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 12662983(Quinolin-3-yl)methanol

生成物 1

HCID 235103313-(Bromomethyl)quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Quinolin-3-ylmethanol was dissolved dichloromethane (15 mL) at 0° C. under nitrogen. Tribromophosphane (2.15 mL, 22 mmol) was added dropwise. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by addition of 10% NaHCO3 solution (5 mL). After 10 minutes, Na2SO4 (30 g) was added. The solvent was filtered and evaporated to provide 3-(bromomethyl)quinoline, which was used without further purification.

後処理

  1. customThe reaction was quenched by addition of 10% NaHCO3 solution (5 mL)
  2. waitAfter 10 minutes
  3. additionNa2SO4 (30 g) was added
  4. filtrationThe solvent was filtered
  5. customevaporated

出典と根拠

ORDレコード
ord-8ffc4ab2fcf34f099aed44bd2ee7c7f1
出典データセット
uspto-grants-2016_04
特許番号
US09315521B2

関連ノート

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