関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 反応物 | 4,6-Dichloroquinoline | HCID 936075 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | HCID 178418218 | HCID 178418218 | 5% |
反応手順
diacetoxypalladium (5.60 mg, 0.02 mmol) was added in one portion to tert-butyl piperidin-4-ylcarbamate (100 mg, 0.50 mmol), 4,6-dichloroquinoline (89 mg, 0.45 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (28.9 mg, 0.05 mmol) and cesium carbonate (488 mg, 1.50 mmol) in DMA (5 mL). The resulting mixture was stirred at 150 °C for 1 hour. LCMS analysis showed formation of a small amount of the desired product. The mixture was heated for a further 2 hours, after which time LCMS analysis showed loss of this small peak. Abandoned.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-af3871564adb47f28d81d03aed7b6196 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
