Triethylamine → HCID 178429490、化合物

HRID 630000

反応式

HRID 630000 の反応式
Br[CH2:2][C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2.[CH3:13][C:14]1[N:19]=[C:18]([SH:20])[N:17]=[C:16]([OH:21])[CH:15]=1.C(N(CC)CC)C>C(O)C>[CH3:13][C:14]1[N:19]=[C:18]([S:20][CH2:2][C:3]2[CH:4]=[N:5][C:6]3[C:11]([CH:12]=2)=[CH:10][CH:9]=[CH:8][CH:7]=3)[N:17]=[C:16]([OH:21])[CH:15]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 235103313-(Bromomethyl)quinolineHCID 178429541HCID 178429541、化合物

生成物 1

HCID 178429490HCID 178429490、化合物収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-(bromomethyl)quinoline, 6-methyl-2-sulfanylpyrimidin-4-ol (853 mg, 6 mmol) and triethylamine (1 mL, 7 mmol) were mixed in ethanol (50 mL). The mixture was stirred at room temperature for 2 hours. After evaporation, water (100 mL) was added. The suspension was filtered and washed with water and ethyl acetate to provide pure titled product (1.7 g, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.21 (s, 3H), 4.54 (s, 2H), 6.01 (s, 1H), 7.58 (m, 1H), 7.70 (m, 1H), 7.94 (m, 2H), 8.35 (s, 1H), 8.96 (s, 1H); M+284.

後処理

  1. customAfter evaporation, water (100 mL)
  2. additionwas added
  3. filtrationThe suspension was filtered
  4. washwashed with water and ethyl acetate

出典と根拠

ORDレコード
ord-6f7e719c75334eb0af7d448ac70a77b7
出典データセット
uspto-grants-2016_04
特許番号
US09315521B2

関連ノート

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