Phosphorus tribromide → Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

HRID 630054ノート

反応式

HRID 630054 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[CH:4][C:3]=1[CH2:14]O.P(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:14][C:3]1[CH:4]=[C:5]([CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])[CH:6]=[CH:7][C:2]=1[Cl:1]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 59589352HCID 59589352、化合物

生成物 1

HCID 66815196Benzenemethanamine, 3-(bromomethyl)-4-chloro-N,N-diethyl-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of {2-chloro-5-[(diethylamino)methyl]phenyl}methanol (3.0 g, 13.2 mmol) in anhydrous dichloromethane (80 mL) was added dropwise phosphorus tribromide (2.5 mL, 26.4 mmol). The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was dried in vacuo, affording {[3-(bromomethyl)-4-chlorophenyl]methyl}diethylamine. The product was used without further purification.

後処理

  1. customThe solvent was evaporated
  2. customThe residue was dried in vacuo

出典と根拠

ORDレコード
ord-0c42fc26846741df9dbd7bc516541f0f
出典データセット
uspto-grants-2016_04
特許番号
US09315521B2

反応ノート

読み込み中…