Phosphorus tribromide → 5-(Bromomethyl)-4-(propan-2-yl)-1,3-thiazole
反応式
[CH3:1][CH:2]([C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH2:9]O)[CH3:3].[Br:11]P(Br)Br>ClCCl>[Br:11][CH2:9][C:8]1[S:7][CH:6]=[N:5][C:4]=1[CH:2]([CH3:3])[CH3:1]参加物
4
実験手順
To a solution of [4-(propan-2-yl)-1,3-thiazol-5-yl]methanol (800 mg, 5.1 mmol) in anhydrous dichloromethane (35 mL) was added tribromophosphane (520 μL, 5.5 mmol). The mixture was stirred at room temperature for 1.5 hours. Dichloromethane was evaporated. The residue was dried in vacuo, affording 5-(bromomethyl)-4-(propan-2-yl)-1,3-thiazole. The crude product was used without further purification.
後処理
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
出典と根拠
- ORDレコード
- ord-d730f002bc544a7686ed391e71e2bd18
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315521B2
反応ノート
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