Phosphorus tribromide → 4-(Bromomethyl)-3,5-dichloropyridine hydrobromide
反応式
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:10])[C:7]=1[CH2:8]O.[Br:11]P(Br)Br>ClCCl>[BrH:11].[Br:11][CH2:8][C:7]1[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=1[Cl:10]参加物
4
実験手順
To a solution of (3,5-dichloropyridin-4-yl)methanol (1.9 g, 10.7 mmol) in anhydrous dichloromethane (75 mL) was added tribromophosphane (1.1 mL, 11.5 mmol). The mixture was stirred at room temperature for 1.5 hours. Dichloromethane was evaporated, and the mixture was co-evaporated with toluene (2×20 mL). The residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dichloropyridine hydrobromide (2.9 g, 98% yield), which was used without further purification.
後処理
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
出典と根拠
- ORDレコード
- ord-f2e1ff0fd508423db620085c0d8e7fcc
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315521B2
反応ノート
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