関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Naphthoic acid | HCID 6847 | — |
| 反応物 | 2,4-Diaminophenol hydrochloride | HCID 8715 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-(1-Naphthyl)-1,3-benzoxazol-5-amine | HCID 650480 | 77% |
反応手順
8 mmol of 2,4-diaminophenol.2HCl and 8 mmol of naphthalene-1-carboxylic acid were dissolved in 10 g of polyphosphoric acid (PPA), and then, the mixed solution was stirred at a temperature of 180° C. for 3 to 4 hours. After completion of the reaction, the reaction solution was cooled, neutralized with 10% NaOH, and filtered by using distilled water for recrystallization in a slow manner, thereby obtaining 1.6 g of 2-(naphthalene-1-yl)benzo[d]oxazole-5-amine (Derivative #2) (yield: 77%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447054B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-e2225ab498f34f34b187be48b2e4d446 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
