Phosphorus tribromide → 4-(Bromomethyl)-3,5-dimethylpyridine

HRID 630279ノート

反応式

HRID 630279 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[CH2:8]O.[Br:11]P(Br)Br>ClCCl>[Br:11][CH2:8][C:7]1[C:2]([CH3:1])=[CH:3][N:4]=[CH:5][C:6]=1[CH3:10]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 22663284(3,5-Dimethylpyridin-4-yl)methanol

生成物 1

HCID 595894034-(Bromomethyl)-3,5-dimethylpyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (3,5-dimethylpyridin-4-yl)methanol (2.55 g, 18.6 mmol) in anhydrous dichloromethane (130 mL) was added tribromophosphane (2.0 mL, 21.1 mmol). The mixture was stirred at room temperature for 5 hours. Dichloromethane was evaporated. The residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dimethylpyridine. The crude product was used without further purification.

後処理

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

出典と根拠

ORDレコード
ord-27e741c8862440c69e5bc06f5c084cc6
出典データセット
uspto-grants-2016_04
特許番号
US09315521B2

反応ノート

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