4-Fluorobenzylamine → HCID 81750967、化合物

反応式

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.F[C:11]1([CH:19]=[CH:18][N:17]=[CH:16][CH2:15]1)[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][C:11]=2[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 673264-Fluorobenzylamine

HCID 867281944-Fluoroisonicotinic acid

生成物 1

HCID 81750967HCID 81750967、化合物収率 55%

実験手順

The title compound was prepared in 55% yield from 4-fluorobenzylamine and 4-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. NMR (500 MHz, DMSO-d6): δ 13.45 (br s, 1H), 8.11 (s, 1H), 8.03 (br s, 1H), 7.83 (d, 1H, J=5.0 Hz), 7.58 (d, 1H, J=5.0 Hz), 7.36-7.42 (m, 1H), 7.16-7.23 (m, 2H), 7.05-7.11 (m, 1H), 4.60 (s, 2H). [M+H] calc'd for C13H11FN2O2, 247. found 247.

出典と根拠

ORDレコード: ord-8ed51ea8fcd2408da63f2663f9d2fc69
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447045B2

反応ノート

読み込み中…

参加物