Imidazole → 4-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloroaniline

HRID 630390ノート

反応式

HRID 630390 の反応式
NC1C=CC(CO)=CC=1Cl.Cl[Si](C(C)(C)C)(C)C.N1C=CN=C1.[Si:24]([O:31][CH2:32][C:33]1[C:39](OC)=[CH:38][C:36]([NH2:37])=[C:35]([Cl:42])[CH:34]=1)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]>CN(C=O)C>[Si:24]([O:31][CH2:32][C:33]1[CH:39]=[CH:38][C:36]([NH2:37])=[C:35]([Cl:42])[CH:34]=1)([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]

参加物

6

反応物 4

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 13843958(4-Amino-3-chlorophenyl)methanol2 回HCID 671456574-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyaniline

生成物 1

HCID 671452954-({[Tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloroaniline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Obtained as a light orange oil (87%) starting from (4-Amino-3-chlorophenyl)methanol (intermediate 45; 2.72 g, 0.016 mol), 4.94 g (0.033 mmol) of cloro(tertbutyl)-dimethylsilane and 3.35 g (0.049 mol) of imidazole in 68 ml DMF and following the experimental procedure as described for intermediate 39.

出典と根拠

ORDレコード
ord-e5fdf61f8e9145a99cc6dba5d126698a
出典データセット
uspto-grants-2016_04
特許番号
US09315463B2

反応ノート

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