Triacetoxyperiodinane → 1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-6-(morpholine-4-carbonyl)-1H-indole-3-carbaldehyde
反応式
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]1[CH:31]=[N:32][C:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([N:47]4[CH2:52][CH2:51][O:50][CH2:49][CH2:48]4)=[O:46])[CH:43]=3)[C:38]([CH2:53][OH:54])=[CH:37]2)=[N:34][CH:35]=1>ClCCl>[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]1[CH:35]=[N:34][C:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([N:47]4[CH2:52][CH2:51][O:50][CH2:49][CH2:48]4)=[O:46])[CH:43]=3)[C:38]([CH:53]=[O:54])=[CH:37]2)=[N:32][CH:31]=1参加物
4
実験手順
Dess Martin periodinane (235 mg, 0.556 mmol, 1.5 eq) was added to the product of 27d) (160 mg, 0.370 mmol, 1.0 eq) in dichloromethane (10 mL) at 0° C. The mixture was stirred for 2 h at room temperature, and then filtered through a pad of celite. The filter was rinsed with dichloromethane and the filtrate was dried over sodium sulfate, and evaporated. White solid. Yield: 140 mg. Mass spectroscopy: m/z: [M+H]+=430.9