2-(Aminomethyl)phenol → 3-[(2-Hydroxybenzyl)amino]pyridine-4-carboxylic acid

HRID 63051

反応式

HRID 63051 の反応式
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].F[C:11]1[CH:19]=[N:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>>[OH:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][NH:1][C:16]1[CH:17]=[N:18][CH:19]=[CH:11][C:12]=1[C:13]([OH:15])=[O:14]

参加物

3

反応物 2

HCID 702672-(Aminomethyl)phenolHCID 3453613-Fluoropyridine-4-carboxylic acid

生成物 1

HCID 867282043-[(2-Hydroxybenzyl)amino]pyridine-4-carboxylic acid収率 2%

実験手順

The title compound was prepared in 2% yield from 2-(aminomethyl)phenol and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.30 (br s, 1H), 9.67 (s, 1H), 8.20 (s, 1H), 7.79 (d, 1H, J=4.9 Hz), 7.54 (d, 1H, J=4.9 Hz), 7.20 (d, 1H, J=7.0 Hz), 7.09 (t, 1H, J=7.6 Hz), 6.84 (d, 1H, J=8.1), 6.84 (dd, 1H, J=7.4 Hz), 4.44 (s, 2H). [M+H] calc'd for C13H12N2O3, 245. found 245.

出典と根拠

ORDレコード
ord-e7e74acefc0448d7a58ce117c2500bd0
出典データセット
uspto-grants-2016_09
特許番号
US09447045B2

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