2-Bromobenzylamine → 3-[(2-Bromobenzyl)amino]pyridine-4-carboxylic acid

反応式

[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].F[C:11]1[CH:19]=[N:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:16]1[CH:17]=[N:18][CH:19]=[CH:11][C:12]=1[C:13]([OH:15])=[O:14]

参加物

反応物 2

HCID 3340722-Bromobenzylamine

HCID 3453613-Fluoropyridine-4-carboxylic acid

生成物 1

HCID 817503783-[(2-Bromobenzyl)amino]pyridine-4-carboxylic acid収率 33%

実験手順

The title compound was prepared in 33% yield from 2-bromobenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. [M+H] calc'd for C13H11BrN2O2, 307, 309. found 307, 309.

出典と根拠

ORDレコード: ord-ca170d50901449aaa052a58a30a1b9d9
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447045B2

反応ノート

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