化工社化工社 化学情報印刷レポート · 研究参考用
Triacetoxyperiodinane → (1-(5-(5-Ethoxy-2-fluorophenyl)pyrimidin-2-yl)-3-(1-hydroxyethyl)-1H-indol-6-yl)(morpholino)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | 5-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 16217468 | — |
| 反応物 | (1-(5-Bromopyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666263 | — |
| 反応物 | HCID 178418573 | HCID 178418573 | — |
| 生成物 | (1-(5-(5-Ethoxy-2-fluorophenyl)pyrimidin-2-yl)-3-(1-hydroxyethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118671990 | — |
反応手順
The target compound was prepared from intermediate 27c in three reaction steps comprising a Suzuki reaction with (5-ethoxy-2-fluorophenyl)boronic acid, an oxidation with Dess-Martin periodinane and a Grignard reaction with methylmagnesium bromide. White solid. Yield: 110 mg
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09315490B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-05bb3ba7f9024c3287587a71a85b346e |
| 出典メモ | uspto-grants-2016_04 |