4-Methylmorpholine → N-(2-Amino-2-oxoethyl)-1-(5-(5-ethyl-2-fluorophenyl)pyrimidin-2-yl)-3-(1-hydroxyethyl)-N-methyl-1H-indole-6-carboxamide

HRID 630543ノート

反応式

HRID 630543 の反応式
CN1CCOCC1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.Cl.[CH3:31][NH:32][CH2:33][C:34]([NH2:36])=[O:35].[CH2:37]([C:39]1[CH:40]=[CH:41][C:42]([F:66])=[C:43]([C:45]2[CH:46]=[N:47][C:48]([N:51]3[C:59]4[C:54](=[CH:55][CH:56]=[C:57]([C:60]([OH:62])=O)[CH:58]=4)[C:53]([CH:63]([OH:65])[CH3:64])=[CH:52]3)=[N:49][CH:50]=2)[CH:44]=1)[CH3:38]>CN(C=O)C>[NH2:36][C:34](=[O:35])[CH2:33][N:32]([CH3:31])[C:60]([C:57]1[CH:58]=[C:59]2[C:54]([C:53]([CH:63]([OH:65])[CH3:64])=[CH:52][N:51]2[C:48]2[N:47]=[CH:46][C:45]([C:43]3[CH:44]=[C:39]([CH2:37][CH3:38])[CH:40]=[CH:41][C:42]=3[F:66])=[CH:50][N:49]=2)=[CH:55][CH:56]=1)=[O:62]

参加物

6

反応物 4

HCID 79724-MethylmorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 138929562-(Methylamino)acetamide hydrochlorideHCID 1186660901-(5-(5-Ethyl-2-fluorophenyl)pyrimidin-2-yl)-3-(1-hydroxyethyl)-1H-indole-6-carboxylic acid

生成物 1

HCID 118666127N-(2-Amino-2-oxoethyl)-1-(5-(5-ethyl-2-fluorophenyl)pyrimidin-2-yl)-3-(1-hydroxyethyl)-N-methyl-1H-indole-6-carboxamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-methylmorpholine (0.107 mL, 0.986 mmol), TBTU (0.191 g, 0.592 mmol) and 2-(methylamino)acetamide hydrochloride (0.123 g, 0.986 mmol) were added to an ice-cooled suspension of 331e) (0.2 g, 0.493 mmol) in DMF (4 mL). The reaction mixture was stirred at room temperature for 16 h and then diluted with ice-cold water. A precipitate was filtered off and dissolved in dichloromethane. The organic phase was washed with sodium hydrogen carbonate solution (20 mL) and brine (20 mL), dried over sodium sulfate and evaporated. The remnant was purified by flash column chromatography [silica gel; dichloromethane with 4% methanol] followed by preparative HPLC. White solid. Yield: 65 mg (28% of theory)

後処理

  1. temperaturecooled
  2. additiondiluted with ice-cold water
  3. filtrationA precipitate was filtered off
  4. dissolutiondissolved in dichloromethane
  5. washThe organic phase was washed with sodium hydrogen carbonate solution (20 mL) and brine (20 mL)
  6. dry with materialdried over sodium sulfate
  7. customevaporated
  8. customThe remnant was purified by flash column chromatography [silica gel; dichloromethane with 4% methanol]

出典と根拠

ORDレコード
ord-85b6c7498c2f4a49a6f611d1aa61adbd
出典データセット
uspto-grants-2016_04
特許番号
US09315490B2

反応ノート

読み込み中…