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2-(Aminomethyl)aniline → 3-[(2-Aminobenzyl)amino]pyridine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Aminomethyl)aniline | HCID 178096 | — |
| 反応物 | 3-Fluoropyridine-4-carboxylic acid | HCID 345361 | — |
| 生成物 | 3-[(2-Aminobenzyl)amino]pyridine-4-carboxylic acid | HCID 77105910 | 9% |
反応手順
The title compound was prepared in 9% yield from 2-aminobenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 8.16 (s, 1H), 7.82 (d, 1H, J=5.0 Hz), 7.56 (d, 1H, J=5.0 Hz), 7.05 (d, 1H, J=7.5 Hz), 6.97 (td, 1H, J=7.8, 1.4 Hz), 6.66 (d, 1H, J=7.9 Hz), 6.52 (td, 1H, J=7.4, 1.0 Hz), 4.35 (s, 2H). [M+H] calc'd for C13H13N3O2, 244. found 244.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447045B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-a6c8efd0809845a2a9fc11e3939ca554 |
| 出典メモ | uspto-grants-2016_09 |