2-Chloro-3-nitro-5-(trifluoromethyl)pyridine → 2-Chloro-5-(trifluoromethyl)pyridin-3-amine

Zink(II)-chloride-dihydrate (4.39 g, 19.5 mmol) is added to a solution of 2-chloro-3-nitro-5-(trifluoromethyl)pyridine (1.00 g, 4.41 mmol) in a ethyl acetate (25 ml), and the resultant suspension is stirred for 2 h at 80° C. After cooling to room temperature, the reaction mixture is slowly added dropwise into an ice cooled saturated sodium hydrogen carbonate solution (100 ml). After warming to room temperature, the resultant suspension is filtered via a celite layer, and the residue is washed four times with ethyl acetate (50 ml each). The filtrate and the washing solution are combined and subsequently washed with a saturated sodium hydrogen carbonate solution, water and a saturated aqueous sodium chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated to dryness. Yield: 0.78 g (90%).

1. temperatureAfter warming to room temperature
2. filtrationthe resultant suspension is filtered via a celite layer
3. washthe residue is washed four times with ethyl acetate (50 ml each)
4. washsubsequently washed with a saturated sodium hydrogen carbonate solution, water
5. dry with materialThe organic phase is dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated to dryness

ORDレコード

ord-196c760511fe4d078382838a66d64b98

出典データセット

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09315724B2