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1-Naphthalenemethanamine → 3-[(Naphthalene-1-ylmethyl)amino]pyridine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Naphthalenemethanamine | HCID 8355 | — |
| 反応物 | 3-Fluoropyridine-4-carboxylic acid | HCID 345361 | — |
| 生成物 | 3-[(Naphthalene-1-ylmethyl)amino]pyridine-4-carboxylic acid | HCID 77105705 | 66% |
反応手順
The title compound was prepared in 66% yield from 1-naphthylmethylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.39 (br s, 1H), 8.25 (s, 1H), 8.15 (d, 1H, J=7.9 Hz), 7.98 (d, 1H, J=7.5 Hz), 7.84-7.89 (m, 2H), 7.45-7.62 (m, 5H), 5.03 (s, 2H). [M+H] calc'd for C17H14N2O2, 279. found 279.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447045B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-d36edc9b096344d9981868c7ada7b1b2 |
| 出典メモ | uspto-grants-2016_09 |