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3-(Trifluoromethyl)benzylamine → 3-{[3-(Trifluoromethyl)benzyl]amino}pyridine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| 反応物 | 3-Fluoropyridine-4-carboxylic acid | HCID 345361 | — |
| 生成物 | 3-{[3-(Trifluoromethyl)benzyl]amino}pyridine-4-carboxylic acid | HCID 77106114 | 39% |
反応手順
The title compound was prepared in 39% yield from 3-trifluoromethyl-benzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.47 (br s, 1H), 8.12 (s, 1H), 7.83 (d, 1H, J=5.0 Hz), 7.74 (s, 1H), 7.57-7.69 (m, 4H), 4.67 (s, 2H). [M+H] calc'd for C14H11F3N2O2, 297. found 297.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447045B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-5246ac3e9aae48f0b1ba438aaa3cf5c3 |
| 出典メモ | uspto-grants-2016_09 |