3-(Trifluoromethoxy)benzylamine → HCID 86728207、化合物
反応式
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8].F[C:15]1[CH:23]=[N:22][CH:21]=[CH:20][C:16]=1[C:17]([OH:19])=[O:18]>>[F:1][C:2]([F:12])([F:13])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH:8][C:20]1[CH:21]=[N:22][CH:23]=[CH:15][C:16]=1[C:17]([OH:19])=[O:18]参加物
3
実験手順
The title compound was prepared in 4% yield from 3-trifluoromethoxy-benzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.47 (br s, 1H), 8.11 (br s, 1H), 7.84 (br s, 1H), 7.59 (s, 1H), 7.24-7.51 (m, 4H), 4.64 (s, 2H). [M+H] calc'd for C14H11F3N2O3, 313. found 313.
出典と根拠
- ORDレコード
- ord-b6517938a332462bb0886ac9efac015b
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447045B2
反応ノート
読み込み中…