3-Fluoropyridine-4-carboxylic acid → HCID 77106318、化合物

HRID 63068

反応式

HRID 63068 の反応式
[CH3:1][C:2]1[O:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.F[C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]>>[CH3:1][C:2]1[O:8][C:5]([CH2:6][NH:7][C:15]2[CH:16]=[N:17][CH:18]=[CH:10][C:11]=2[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 3453613-Fluoropyridine-4-carboxylic acidHCID 27246835-Methyl-2-furylmethylamine

生成物 1

HCID 77106318HCID 77106318、化合物収率 34%

実験手順

The title compound was prepared in 34% yield from 5-methylfurfurylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.45 (br s, 1H), 8.35 (s, 1H), 7.86 (d, 1H, J=5.0 Hz), 7.77 (br s, 1H), 7.57 (d, 1H, J=5.0 Hz), 6.24 (d, 1H, J=2.9 Hz), 6.00 (d, 1H, J=2.0 Hz), 4.50 (s, 2H), 2.23 (s, 3H). [M+H] calc'd for C12H12N2O3, 233. found 233.

出典と根拠

ORDレコード
ord-f70c0c2577eb4b678c5ffdf95e2f770f
出典データセット
uspto-grants-2016_09
特許番号
US09447045B2

関連ノート

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