化工社化工社 化学情報印刷レポート · 研究参考用
4-Hydroxybenzoic Acid → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybenzoic Acid | HCID 135 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | (S)-2-methyl-1-butanol | HCID 2723602 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | 83% |
反応手順
4.0 g of p-hydroxybenzoic acid and 12.5 g of (S)-(-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while the generated water was removed out. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. After the resulting solution was dried and concentrated, the concentrate was purified by column chromatography to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248446 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-4871f52327694f1cbe2e0f27dd59dbfe |
| 出典メモ | uspto-grants-1993_09 |