4-Chlorophenyl 3-(2-fluoropropan-2-yl)isoxazol-5-ylcarbamate → 1-(3-(2-Fluoropropan-2-yl)isoxazol-5-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[O:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([OH:18])=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9]=[CH:8][N:7]=1.[F:22][C:23]([C:26]1[CH:30]=[C:29]([NH:31][C:32](=O)[O:33]C2C=CC(Cl)=CC=2)[O:28][N:27]=1)([CH3:25])[CH3:24]>CN(C=O)C>[F:22][C:23]([C:26]1[CH:30]=[C:29]([NH:31][C:32]([NH:1][C:2]2[CH:21]=[CH:20][CH:19]=[C:4]([O:5][C:6]3[C:15]4[C:10](=[CH:11][C:12]([OH:18])=[C:13]([O:16][CH3:17])[CH:14]=4)[N:9]=[CH:8][N:7]=3)[CH:3]=2)=[O:33])[O:28][N:27]=1)([CH3:24])[CH3:25]参加物
4
反応条件
- 温度
- 60 °C