Cesium carbonate → 3-(6,7-Dimethoxyquinazolin-4-yloxy)-2-fluoroaniline

HRID 631587ノート

反応式

HRID 631587 の反応式
C(=O)([O-])[O-].[Cs+].[Cs+].C1COCC1.CN(C=O)C.[NH2:17][C:18]1[C:19]([F:25])=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1.Cl[C:27]1[C:36]2[C:31](=[CH:32][C:33]([O:39][CH3:40])=[C:34]([O:37][CH3:38])[CH:35]=2)[N:30]=[CH:29][N:28]=1>ClCCl>[CH3:38][O:37][C:34]1[CH:35]=[C:36]2[C:31](=[CH:32][C:33]=1[O:39][CH3:40])[N:30]=[CH:29][N:28]=[C:27]2[O:24][C:20]1[C:19]([F:25])=[C:18]([CH:23]=[CH:22][CH:21]=1)[NH2:17]

参加物

6

反応物 4

HCID 10796Cesium carbonateHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 198960373-Amino-2-fluorophenolHCID 21974620tetrahydrofuran N,N-dimethylformamide

生成物 1

HCID 178195183-(6,7-Dimethoxyquinazolin-4-yloxy)-2-fluoroaniline収率 42.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred slurry of cesium carbonate (10.25 g, 31.47 mmol) in a 9:1 mixture of THF/DMF (100 mL) at rt, was added 3-amino-2-fluorophenol (2.00 g, 15.74 mmol) in one portion. After stirring for 30 min at rt, 4-chloro-6,7-dimethoxyquinazoline (3.54 g, 15.74 mmol) was added and the reaction mixture was heated at 50° C. for 18 h. The reaction was cooled to rt, then diluted with dichloromethane. The solution was washed with water, then brine, and dried over MgSO4. Filtration followed by concentration under reduced pressure gave a solid that was triturated with a mixture of 10% dichloromethane in ethyl acetate. Filtration afforded 3-(6,7-dimethoxyquinazolin-4-yloxy)-2-fluoroaniline (2.10 g, 42%) as a colorless solid. 1H NMR (400 MHz, DMSO-d6) δ 8.56 (s, 1H), 7.54 (s, 1H), 7.40 (s, 1H), 6.93 (dd, J=8.4, 8.4 Hz, 1H), 6.71 (dd, J=8.4, 8.4 Hz, 1H), 6.53 (m, 1H), 5.37 (brs, 2H), 3.99 (s, 3H), 3.98 (s, 3H); LC-MS (ESI) m/z 316 (M+H)+.

後処理

  1. temperaturethe reaction mixture was heated at 50° C. for 18 h
  2. temperatureThe reaction was cooled to rt
  3. washThe solution was washed with water
  4. dry with materialbrine, and dried over MgSO4
  5. filtrationFiltration
  6. concentrationfollowed by concentration under reduced pressure
  7. customgave a solid
  8. customthat was triturated with a mixture of 10% dichloromethane in ethyl acetate
  9. filtrationFiltration

出典と根拠

ORDレコード
ord-edf64ee2fccc493eba1a70f721538b4b
出典データセット
uspto-grants-2016_04
特許番号
US09320739B2

反応ノート

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