Pentanenitrile, 4,4-dimethyl-3-oxo- → 3-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine

HRID 631669

反応式

HRID 631669 の反応式
[NH:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)[NH2:2].[CH3:9][C:10]([CH3:17])([CH3:16])[C:11](=O)[CH2:12][C:13]#[N:14]>>[C:10]([C:11]1[CH:12]=[C:13]([NH2:14])[N:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)[N:2]=1)([CH3:17])([CH3:16])[CH3:9]

参加物

3

反応物 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 109095193-Hydrazinopyridine

生成物 1

HCID 461967753-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine収率 77.3%

実験手順

Following the procedure in Example 161A Step 3, 3-hydrazinylpyridine (501 mg, 4.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (437 mg, 4.0 mmol) were reacted to give 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-amine (667 mg, 3.09 mmol, 77%), LC-MS (ESI) m/z 217 (M+H)+.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-529e66e89a164ed6a369230e2e7b8c01
出典データセット
uspto-grants-2016_04
特許番号
US09320739B2

関連ノート

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