反応式
[C:1]1([CH3:26])[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[C:11]([NH:12][C:13](=[O:21])[O:14]C3C=CC=CC=3)=[CH:10][C:9]([C:22]([F:25])([F:24])[F:23])=[N:8]2)[CH:2]=1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][C:38]=1[O:39][CH3:40])[N:35]=[CH:34][N:33]=[C:32]2[S:41][C:42]1[CH:43]=[C:44]([CH:46]=[CH:47][CH:48]=1)[NH2:45]>>[CH3:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][C:38]=1[O:39][CH3:40])[N:35]=[CH:34][N:33]=[C:32]2[S:41][C:42]1[CH:43]=[C:44]([NH:45][C:13]([NH:12][C:11]2[N:7]([C:3]3[CH:2]=[C:1]([CH3:26])[CH:6]=[CH:5][CH:4]=3)[N:8]=[C:9]([C:22]([F:25])([F:24])[F:23])[CH:10]=2)=[O:21])[CH:46]=[CH:47][CH:48]=1.[C:1]1([CH3:26])[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[C:11]([NH:12][C:13](=[O:14])[NH2:33])=[CH:10][C:9]([C:22]([F:25])([F:24])[F:23])=[N:8]2)[CH:2]=1参加物
4
反応物 2
生成物 2
実験手順
The title compound was prepared from the carbamate from Example 338A (108 mg, 0.30 mmol) and 3-(6,7-dimethoxyquinazolin-4-ylthio)aniline (94 mg, 0.30 mmol) using the procedure in Example 115C to give 14346,7-dimethoxyquinazolin-4-ylthio)phenyl)-3-(1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)urea (137 mg, 0.24 mmol, 79%). 1H NMR (300 MHz, DMSO-d6) δ 9.31 (s, 1H), 8.76 (s, 1H), 8.68 (s, 1H), 7.78 (s, 1H), 7.52-7.25 (m, 9H), 6.86 (s, 1H), 3.98 (s, 6H), 2.41 (s, 3H); LC-MS (ESI) m/z 581 (M+H)+.
出典と根拠
- ORDレコード
- ord-72552bd4b1564a558dbf51f37c02142f
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09320739B2
関連ノート
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