Pentanenitrile, 4,4-dimethyl-3-oxo- → 3-tert-Butyl-1-(3-fluorophenyl)-1H-pyrazol-5-amine

反応式

Cl.[F:2][C:3]1[CH:4]=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[CH3:11][C:12]([CH3:19])([CH3:18])[C:13](=O)[CH2:14][C:15]#[N:16]>>[C:12]([C:13]1[CH:14]=[C:15]([NH2:16])[N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([F:2])[CH:4]=2)[N:10]=1)([CH3:19])([CH3:18])[CH3:11]

参加物

反応物 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

HCID 27239143-Fluorophenylhydrazine hydrochloride

生成物 1

HCID 461168973-tert-Butyl-1-(3-fluorophenyl)-1H-pyrazol-5-amine収率 67%

実験手順

The title compound was prepared from 3-Fluorophenylhydrazine hydrochloride (1.30 g, 8.0 mmol) and 4,4-Dimethyl-3-oxopentanenitrile (1.0 g, 8.0 mmol) using the procedure in Example 161A Step 3 to give 3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-amine (1.24 g, 5.32 mmol, 67%). 1H NMR (300 MHz, DMSO-d6) δ 7.49-7.41 (m, 3H), 7.10 (br s, 1H), 5.41 (s, 1H), 5.35 (br s, 2H), 1.21 (s, 9H); LC-MS (ESI) m/z 234 (M+H)+.

出典と根拠

ORDレコード: ord-caa60fe2a46a41d289f6c19530a19f26
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09320739B2

反応ノート

読み込み中…

参加物