Pentanenitrile, 4,4-dimethyl-3-oxo- → HCID 66876507、化合物

HRID 631739

反応式

HRID 631739 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[CH3:13][C:14]([CH3:21])([CH3:20])[C:15](=O)[CH2:16][C:17]#[N:18]>>[C:14]([C:15]1[CH:16]=[C:17]([NH2:18])[N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:8][CH:7]=2)[N:10]=1)([CH3:21])([CH3:20])[CH3:13]

参加物

3

反応物 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 1362004-(Trifluoromethyl)phenylhydrazine

生成物 1

HCID 66876507HCID 66876507、化合物収率 60.1%

実験手順

The title compound was prepared from 4-(trifluoromethyl)-phenylhydrazine (1.41 g, 8.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (1.0 g, 8.0 mmol) using the procedure in Example 161A Step 3 to give to give 3-tert-butyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (1.36 g, 4.81 mmol, 60%). 1H NMR (300 MHz, DMSO-d6) δ 7.81 (d, 2H), 7.80 (d, 2H), 5.44 (s, 3H), 1.22 (s, 9H); LC-MS (ESI) m/z 284 (M+H)+.

後処理

  1. customto give

出典と根拠

ORDレコード
ord-02d5a31b4afb4125ac5d9ab27c2410b3
出典データセット
uspto-grants-2016_04
特許番号
US09320739B2

関連ノート

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