4-Fluoroaniline → 2-chloro-5-ethyl-N-(4-fluorophenyl)-6-methylpyrimidin-4-amine

HRID 63176

反応式

HRID 63176 の反応式
ClC1N=C(NC2CCCCC2)C(C)=C(C)N=1.[Cl:17][C:18]1[N:23]=[C:22](Cl)[C:21]([CH2:25][CH3:26])=[C:20]([CH3:27])[N:19]=1.ClC1N=C(Cl)C(C)=C(C)N=1.[F:38][C:39]1[CH:45]=[CH:44][C:42]([NH2:43])=[CH:41][CH:40]=1>>[Cl:17][C:18]1[N:23]=[C:22]([NH:43][C:42]2[CH:44]=[CH:45][C:39]([F:38])=[CH:40][CH:41]=2)[C:21]([CH2:25][CH3:26])=[C:20]([CH3:27])[N:19]=1

参加物

5

反応物 4

HCID 97314-FluoroanilineHCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 824606262-chloro-N-cyclohexyl-5,6-dimethylpyrimidin-4-amineHCID 897610702,4-Dichloro-5-ethyl-6-methylpyrimidine

生成物 1

HCID 1178176582-chloro-5-ethyl-N-(4-fluorophenyl)-6-methylpyrimidin-4-amine

実験手順

The titled compound was synthesized according to the procedure described for preparation of 2-chloro-N-cyclohexyl-5,6-dimethylpyrimidin-4-amine (Example 1, Step D) using 2,4-dichloro-5-ethyl-6-methylpyrimidine instead 2,4-dichloro-5,6-dimethylpyrimidine and 4-fluoroaniline instead of cyclohexylamine. The titled compound was obtained as a white solid. MS (ESI) m/z 266.7, 268.7 (M+1)+.

後処理

  1. customThe titled compound was synthesized

出典と根拠

ORDレコード
ord-7d6665336df9400aabbf57fe305a1b62
出典データセット
uspto-grants-2016_09
特許番号
US09447051B2

関連ノート

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