Cesium carbonate → 6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester

HRID 632043ノート

反応式

HRID 632043 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:13][CH2:12]2)=[C:7](Br)[N:6]=1)=[O:4].[Cl:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].C(Cl)Cl.[Pd](Cl)Cl.O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:13][CH2:12]2)=[C:7]([C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:15])[CH:21]=2)[N:6]=1)=[O:4]

参加物

6

反応物 3

HCID 10796Cesium carbonateHCID 2734323(3-Chlorophenyl)boronic acidHCID 866747506-Bromo-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester

生成物 1

HCID 710879366-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester収率 71%

試薬・触媒・溶媒 2

HCID 178418807HCID 178418807、化合物触媒HCID 312751,4-Dioxane溶媒

反応条件

温度
110 °C

実験手順

6-Bromo-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester (0.1 g, 0.4 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.08 g, 0.5 mmol), 1,1′-bis(diphenylphosphino)-ferrocene-palladium(II)dichloride methylene chloride adduct (CAN 95464-05-4, 50 mg) and cesium carbonate (CAN 534-17-8, 0.2 g, 0.6 mmol) was added into 1,4-dioxane (10 mL) under nitrogen atmosphere. The mixture was stirred for 12 h at 110° C. Subsequently, the mixture was concentrated to give crude product. The crude product was purified by a flash column chromatography (silica gel, 5 g, 20% ethyl acetate in petroleum ether) to give product (80 mg, 71%); MS: (EI) m/e 288.1 [M+H]+.

後処理

  1. concentrationSubsequently, the mixture was concentrated
  2. customto give crude product
  3. customThe crude product was purified by a flash column chromatography (silica gel, 5 g, 20% ethyl acetate in petroleum ether)

出典と根拠

ORDレコード
ord-a51bfaf1266943c6bb2744fc7c38ac62
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

反応ノート

読み込み中…