Sodium Cyanide → 5-Methylpicolinonitrile

HRID 632045

反応式

HRID 632045 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[C-:9]#[N:10].[Na+]>CS(C)=O>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([C:9]#[N:10])=[N:3][CH:4]=1

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 27746352-Fluoro-5-methylpyridine

生成物 1

HCID 741835-Methylpicolinonitrile収率 249.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
150 °C

実験手順

2-Fluoro-5-methylpyridine (CAN 2369-19-9, 50 g, 90 mmol) and sodium cyanide (CAN 143-33-9, 70 g, 1.43 mol) were dissolved in DMSO (200 mL), the mixture was stirred for 3 days at 150° C. The mixture was cooled to room temperature, ice water (200 mL) was added and the product was obtained as red solid (26.5 g, 50%) by filtration and drying; MS (EI): m/e 119.1 [M+H]+.

後処理

  1. temperatureThe mixture was cooled to room temperature

出典と根拠

ORDレコード
ord-a2d02657fadf4d4cb7decf83e003a87a
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

関連ノート

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