2-(5-Methyl-1,2,4-oxadiazol-3-yl)propan-2-amine → 6-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 632050ノート

反応式

HRID 632050 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH3:17])[CH:5]=[CH:6][CH:7]=1.[CH3:18][C:19]([CH3:27])([C:21]1[N:25]=[C:24]([CH3:26])[O:23][N:22]=1)[NH2:20]>>[CH3:18][C:19]([NH:20][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH3:17])=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:21]1[N:25]=[C:24]([CH3:26])[O:23][N:22]=1)[CH3:27]

参加物

3

反応物 2

HCID 435592512-(5-Methyl-1,2,4-oxadiazol-3-yl)propan-2-amineHCID 710878026-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid

生成物 1

HCID 710936216-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid (Example 49 e) and α,α,5-trimethyl-1,2,4-oxadiazole-3-methanamine (CAN 1153831-97-0) as starting materials, MS (D): 371.1 [M+H]+.

出典と根拠

ORDレコード
ord-0004fa6ab43b4da9aa0c305df733c4fc
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

反応ノート

読み込み中…