関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| 反応物 | 6-Bromo-5-chloropyridine-2-carboxylic acid | HCID 66557809 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid | HCID 71087619 | 32.6% |
反応手順
Under nitrogen atmosphere, 6-bromo-5-chloro-pyridine-2-carboxylic acid (0.38 g, 1.6 mmol), 3-chlorophenylboronic acid (CAN 63503-60-6, 0.33 g, 2.1 mmol), 1,1′-bis(diphenylphosphino)-ferrocene-palladium(II) dichloride methylene chloride complex (CAN 95464-05-4, 30 mg) and cesium carbonate (CAN 534-17-8, 1.6 g, 4.8 mmol) was added into DMF (30 mL). The mixture was stirred at 80° C. overnight. After evaporation of solvents, the crude product was purified by column chromatography (silica gel, 12 g, petroleum ether/ethyl acetate 4/1 firstly, then methanol/methylene chloride 1/10) to give the title compound (0.14 g, 32%) as brown solid; MS (EI): m/e=268.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09321727B2 |
|---|
| 出典データセット | uspto-grants-2016_04 |
|---|
| ORD ID | ord-c6330391e26a496a8c175eb0e4642b3c |
|---|
| 出典メモ | uspto-grants-2016_04 |
|---|
