1-(2-Amino-2-methylpropoxy)-2-methoxyethane → 6-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [2-(2-methoxy-ethoxy)-1,1-dimethyl-ethyl]-amide

HRID 632198

反応式

HRID 632198 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[N:17]2[CH2:20][C:19]([F:22])([F:21])[CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[CH3:23][O:24][CH2:25][CH2:26][O:27][CH2:28][C:29]([NH2:32])([CH3:31])[CH3:30]>>[CH3:23][O:24][CH2:25][CH2:26][O:27][CH2:28][C:29]([NH:32][C:14]([C:12]1[CH:11]=[CH:10][C:9]([N:17]2[CH2:20][C:19]([F:22])([F:21])[CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:15])([CH3:31])[CH3:30]

参加物

3

反応物 2

HCID 645371681-(2-Amino-2-methylpropoxy)-2-methoxyethaneHCID 710876736-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid

生成物 1

HCID 711056286-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [2-(2-methoxy-ethoxy)-1,1-dimethyl-ethyl]-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 140 a) and 2-(2-methoxy-ethoxy)-1,1-dimethyl-ethylamine (CAN 947723-29-7) as starting materials, MS (EI): m/e=454.1 [M+H]+.

出典と根拠

ORDレコード
ord-98dc535223ab47f6865d789681853a51
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

関連ノート

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