化工社化工社 化学情報印刷レポート · 研究参考用
(2S)-2-amino-N,4,4-trimethyl-pentanamide → (S)-5-Cyclopropyl-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S)-2-amino-N,4,4-trimethyl-pentanamide | HCID 57635521 | — |
| 反応物 | 5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid | HCID 71087254 | — |
| 反応物 | 5-Cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid | HCID 71087560 | — |
| 生成物 | (S)-5-Cyclopropyl-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamide | HCID 71087531 | — |
反応手順
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid (which can e.g. be prepared in a similar manner than 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b)) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials, MS (EI): m/e=418.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321727B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-39722bd94f9b436da3ae0023a7c02968 |
| 出典メモ | uspto-grants-2016_04 |