反応式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH2:3][CH2:2]1.C1(C2C=CC(C(O)=O)=NC=2OCC2CCCO2)CC1.[CH3:40][C:41]([CH3:49])([C:43]1[N:47]=[C:46]([CH3:48])[O:45][N:44]=1)[NH2:42]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:42][C:41]([C:43]3[N:47]=[C:46]([CH3:48])[O:45][N:44]=3)([CH3:49])[CH3:40])=[O:20])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[CH2:2][CH2:3]1参加物
4
反応物 3
生成物 1
実験手順
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid (which can e.g. be prepared in a similar manner than 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b)) and α,α,5-trimethyl-1,2,4-oxadiazole-3-methanamine (CAN 1153831-97-0) as starting materials, MS (EI): m/e=401.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-1091fe236efe4dfa816bdab656084397
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321727B2
関連ノート
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