3,3-Difluoroazetidine hydrochloride → 5-(3,3-Difluoro-azetidin-1-yl)-6-(3-methyl-oxetan-3-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide
反応式
[CH3:1][C:2]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](Br)=[C:14]([O:19][CH2:20][C:21]2([CH3:25])[CH2:24][O:23][CH2:22]2)[N:13]=1)=[O:11])([C:4]1[S:5][CH:6]=[CH:7][N:8]=1)[CH3:3].Cl.[F:27][C:28]1([F:32])[CH2:31][NH:30][CH2:29]1>>[CH3:1][C:2]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([N:30]2[CH2:31][C:28]([F:32])([F:27])[CH2:29]2)=[C:14]([O:19][CH2:20][C:21]2([CH3:25])[CH2:24][O:23][CH2:22]2)[N:13]=1)=[O:11])([C:4]1[S:5][CH:6]=[CH:7][N:8]=1)[CH3:3]参加物
3
反応物 2
生成物 1
実験手順
The title compound was synthesized in analogy to Example 288b, using 5-bromo-6-(3-methyl-oxetan-3-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide (Example 281c) and 3,3-difluoroazetidine hydrochloride as starting materials, MS (EI): m/e=439.3 [M+H]+.