Hydrochloric Acid → 2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine hydrochloride
反応式
C(OC(=O)[NH:7][C:8]([CH3:19])([C:13]1[N:17]=[C:16]([CH3:18])[O:15][N:14]=1)[CH2:9][CH:10]1[CH2:12][CH2:11]1)(C)(C)C.[ClH:21]>CO>[ClH:21].[CH:10]1([CH2:9][C:8]([NH2:7])([CH3:19])[C:13]2[N:17]=[C:16]([CH3:18])[O:15][N:14]=2)[CH2:12][CH2:11]1参加物
4
実験手順
To a solution of [2-cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-carbamic acid tert-butyl ester (0.4 g, 1.43 mmol) in methanol (10 mL) was added hydrochloric acid (4N in dioxane, 3.5 mL, 14.8 mmol) and the reaction mixture was stirred at ambient temperature for 4 hours. The organic layer was washed with brine (20 mL), dried over anhydrous Na2SO4 and concentrated to give the title product (0.25 g, 81%) as a light yellow solid. 1H-NMR (DMSO, 400 MHz): 0.010-0.02 (m, 2H); 0.38-0.42 (m, 2H); 0.61-0.63 (m, 1H); 1.67 (s, 3H); 1.78-1.91 (m, 2H); 2.66 (s, 3H); 8.89 (br s, 3H).