Ethyl 2-amino-2-ethylbutanoate → 2-{[5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

HRID 632439

反応式

HRID 632439 の反応式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[S:10]([CH2:13][CH:14]([CH3:16])[CH3:15])(=[O:12])=[O:11])[CH2:3][CH2:2]1.[CH2:20]([O:22][C:23](=[O:30])[C:24]([NH2:29])([CH2:27][CH3:28])[CH2:25][CH3:26])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:30])[C:24]([NH:29][C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([S:10]([CH2:13][CH:14]([CH3:15])[CH3:16])(=[O:11])=[O:12])[N:8]=1)=[O:19])([CH2:27][CH3:28])[CH2:25][CH3:26])[CH3:21]

参加物

3

反応物 2

HCID 437603Ethyl 2-amino-2-ethylbutanoateHCID 710877315-Cyclopropyl-6-(isobutylsulfonyl)picolinic acid

生成物 1

HCID 710877582-{[5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

実験手順

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(isobutylsulfonyl)picolinic acid (Example 351 b) and 2-amino-2-ethyl-butanoic acid ethyl ester (CAN 189631-96-7) as starting materials. MS (EI): m/e=425.4 [M+H]+.

出典と根拠

ORDレコード
ord-fbd5b6d27b4a435cac2e6e23c2b0ee8a
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

関連ノート

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