Hydrochloric Acid → 2-cyclopentyl N-piperidin-3-yl-L-leucinate dihydrochloride

HRID 632561ノート

反応式

HRID 632561 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C@H:15]([C:20]([O:22][CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:9]1)=O)(C)(C)C.[ClH:28]>ClCCl.O1CCOCC1>[ClH:28].[ClH:28].[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C@H:15]([C:20]([O:22][CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:9]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 866864133-((S)-1-cyclopentyloxycarbonyl-3-methyl-butylamino)-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 866864142-cyclopentyl N-piperidin-3-yl-L-leucinate dihydrochloride収率 24%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 3-((S)-1-cyclopentyloxycarbonyl-3-methyl-butylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.840 g, 2.20 mmol) in dichloromethane (5 mL) was added 4M hydrogen chloride in dioxane (10 mL). The reaction was stirred at room temperature for 90 minutes and then concentrated to give the product (184 mg, 24% yield). LC/MS: m/z 283 [M+H]+

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-65dbc7940e7b4010826560512f4aa94a
出典データセット
uspto-grants-2016_04
特許番号
US09321718B2

反応ノート

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