Potassium Carbonate → 2-Bromo-3-{[(4-methyl-2-pyridinyl)methyl]oxy}pyridine

HRID 63271

反応式

HRID 63271 の反応式
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl.Cl[CH2:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=1>CN(C=O)C>[Br:1][C:2]1[C:7]([O:8][CH2:17][C:18]2[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 230702-Bromo-3-pyridinolHCID 200610712-(Chloromethyl)-4-methylpyridine hydrochloride

生成物 1

HCID 866705442-Bromo-3-{[(4-methyl-2-pyridinyl)methyl]oxy}pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-bromo-3-pyridinol (commercially available, e.g. from Aldrich) (2.9 g) and potassium carbonate (6.94 g) in DMF (25 ml) was stirred for 20 min before adding 2-(chloromethyl)-4-methylpyridine hydrochloride (for preparation see WO 2008/141011) (3 g). This was stirred at room temperature overnight. The reaction mixture was poured into ice/water and the solid formed was collected by filtration, washed with hexane and dried to give the title compound, 2.87 g (61%).

後処理

  1. stirringThis was stirred at room temperature overnight
  2. customthe solid formed
  3. filtrationwas collected by filtration
  4. washwashed with hexane
  5. customdried

出典と根拠

ORDレコード
ord-0bf4c988ac2a4d789f37b19f8861252e
出典データセット
uspto-grants-2016_09
特許番号
US09447074B2

関連ノート

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