Itaconic acid → 1-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid

HRID 632767ノート

反応式

HRID 632767 の反応式
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][N:5]([CH3:7])[CH:6]=1.O.[C:10]([OH:18])(=[O:17])[C:11]([CH2:13][C:14](O)=[O:15])=[CH2:12]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([N:8]2[C:14](=[O:15])[CH2:13][CH:11]([C:10]([OH:18])=[O:17])[CH2:12]2)=[N:4][N:5]([CH3:7])[CH:6]=1

参加物

5

反応物 3

HCID 811Itaconic acidHCID 962WaterHCID 27352834-bromo-1-methyl-1H-pyrazol-3-amine

生成物 1

HCID 1180618811-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
120 °C

実験手順

To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (312 mg) in a mixed solvent of water (2.0 mL) and toluene (2.0 mL) was added itaconic acid (245 mg). The reaction mixture was stirred at 120° C. for 5 hr, and the solvent was evaporated under reduced pressure. The residue was used for the next step without purification.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was used for the next step without purification

出典と根拠

ORDレコード
ord-e2c31f9bde1545b2bcfda8189e8bfbc2
出典データセット
uspto-grants-2016_04
特許番号
US09321757B2

反応ノート

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