Phosphorus oxychloride → 4-Chloro-5-iodo-6-methylpyrimidine
反応式
O[C:2]1[C:7]([I:8])=[C:6]([CH3:9])[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:12]>>[Cl:12][C:2]1[C:7]([I:8])=[C:6]([CH3:9])[N:5]=[CH:4][N:3]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
A suspension of 90 g (0.38 mol) 4-hydroxy-5-iodo-6-methylpyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (90 g; 93%).
後処理
- concentrationThe reaction mixture is concentrated under reduced pressure
- additionthe residue is poured
- custominto crushed ice
- filtrationThe precipitated solid is collected by filtration
- washwashed with water
- customAfter drying
出典と根拠
- ORDレコード
- ord-434e92dce0cc4bbd838a2c387c442456
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321771B2
反応ノート
読み込み中…