Phosphorus oxychloride → 4-Chloro-6-ethyl-5-iodopyrimidine

HRID 632877

反応式

HRID 632877 の反応式
O[C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:13]>>[Cl:13][C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 1784377446-ethyl-5-iodo-1H-pyrimidin-4-one

生成物 1

HCID 109784874-Chloro-6-ethyl-5-iodopyrimidine

反応条件

温度
90 °C

実験手順

A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionthe residue is poured
  3. custominto crushed ice
  4. filtrationThe precipitated solid is collected by filtration
  5. washwashed with water
  6. customAfter drying

出典と根拠

ORDレコード
ord-183e56c017914ce48ce8cdeb73f423ed
出典データセット
uspto-grants-2016_04
特許番号
US09321771B2

関連ノート

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