2-Methyl-6-(trifluoromethyl)nicotinoyl chloride → N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide

HRID 632981ノート

反応式

HRID 632981 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[I:9].[F:10][C:11]([F:23])([F:22])[C:12]1[N:17]=[C:16]([CH3:18])[C:15]([C:19](Cl)=[O:20])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:19]([C:15]2[C:16]([CH3:18])=[N:17][C:12]([C:11]([F:23])([F:10])[F:22])=[CH:13][CH:14]=2)=[O:20])=[CH:4][C:3]=1[I:9]

参加物

3

反応物 2

HCID 27756752-Methyl-6-(trifluoromethyl)nicotinoyl chlorideHCID 218749544-Chloro-3-iodoaniline

生成物 1

HCID 66877122N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide

実験手順

Procedure D was performed with 4-chloro-3-iodoaniline (225 mg, 0.889 mmol) and 6-(trifluoromethyl)-2-methylpyridine-3-carbonyl chloride (237 mg, 0/93 mmol, 1.05 eq) at 0° C. for 30 minutes. The crude residue was purified by silica gel chromatography (2-50% ethyl acetate/hexanes) to yield N-(4-chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a white solid.

後処理

  1. customThe crude residue was purified by silica gel chromatography (2-50% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-15797ecf73c44352af4473b52998a936
出典データセット
uspto-grants-2016_04
特許番号
US09321761B2

反応ノート

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