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Acetonitrile → 3-(4-Bromothiophen-2-yl)-3-hydroxypropanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| 生成物 | 3-(4-Bromothiophen-2-yl)-3-hydroxypropanenitrile | HCID 86694590 | — |
反応手順
Addition of CH3CN to 4-bromothiophene-2-carbaldehyde following the method used in Example 2 gave 3-(4-bromothiophen-2-yl)-3-hydroxypropanenitrile as a light brown oil which was used in the next step without additional purification. Yield (1.95 g, 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447078B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-0b4c34a7edb944d7980955e9f1862dbf |
| 出典メモ | uspto-grants-2016_09 |